Basal Nucleotide Levels, Release, and Metabolism in Normal and Cystic Fibrosis Airways
نویسندگان
چکیده
منابع مشابه
Cystic fibrosis, atopy, and airways lability.
In a survey of cystic fibrosis (CF) in the Avon area, 48 children with CF from 40 families together with 71 of their parents were studied by spirometry, exercise tests, and pinch tests. A control group of 42 young adults was similarly tested; control data for children were taken from previously published work. The prevalence of atopy (any positive prick test) in children with CF was 48%. Sensit...
متن کاملMucous solids and liquid secretion by airways: studies with normal pig, cystic fibrosis human, and non-cystic fibrosis human bronchi.
To better understand how airways produce thick airway mucus, nonvolatile solids were measured in liquid secreted by bronchi from normal pig, cystic fibrosis (CF) human, and non-CF human lungs. Bronchi were exposed to various secretagogues and anion secretion inhibitors to induce a range of liquid volume secretion rates. In all three groups, the relationship of solids concentration (percent nonv...
متن کاملIncreased arginase activity in cystic fibrosis airways.
RATIONALE Airway nitric oxide concentrations are reduced in cystic fibrosis (CF). Arginases compete for L-arginine, the substrate of nitric oxide synthesis. OBJECTIVES We hypothesized that increased arginase activity may be one factor contributing to nitric oxide deficiency in CF. MEASUREMENTS We therefore studied sputum arginase activity, exhaled nitric oxide, and pulmonary function in pat...
متن کاملEndogenous and nitrovasodilator-induced release of NO in the airways of end-stage cystic fibrosis patients.
A variety of isoforms of nitric oxide (NO) synthases are constitutively expressed in human airway and vascular endothelial cells continuously generating NO. NO plays an important role in regulating lung function in health and disease including modulation of pulmonary vascular resistance, airway calibre and host defence. Production of NO and its consumption by fluid-phase reactions can be detect...
متن کاملBasal-like cells constitute the proliferating cell population in cystic fibrosis airways.
RATIONALE Cystic fibrosis airways are recurrently exposed to noxious stimuli, leading to epithelial injury. Previous reports suggest that cystic fibrosis airway epithelia may respond to injury by increasing proliferation. OBJECTIVES We sought to determine the characteristics of the proliferating cell population in cystic fibrosis airways. METHODS Six cystic fibrosis and six normal lung sect...
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ژورنال
عنوان ژورنال: Molecular Medicine
سال: 2000
ISSN: 1076-1551,1528-3658
DOI: 10.1007/bf03401831